Don't expand-file-name, just error
An insight from learning to write fast #elisp: "just-in-case" code can make things slower.
Example situation: you want to ensure that a provided string is an absolute filename, so you wrap it in expand-file-name or file-truename. But these are expensive. Instead, if you know it's usually going to be absolute, just assert that it is:
(unless (file-name-absolute-p PATH) (error "Expected absolute filename but got: %s" PATH))
… and then proceed without ever calling expand-file-name.
Bonus tip: the other use of expand-file-name is faster with file-name-concat instead.
Alternatively, this is also good:
(let (file-name-handler-alist)
(expand-file-name PATH))